[N-clex] CCB(~dipine)

- diltiazam, verapamil

- Ca(말초혈관수축), CCB(말초혈관이완, 심수축력 약화)

효과)

- vasodilation, ↓ cardiac contractility, slow SA-AV conduct(서맥)

indication)

- A-fib, flutter, HTN, unstable angina

S/E)

- dysrhythmia

- peripheral edema

- hepatotoxicity

- G-I distress

- ↓BP(SBP 90↓ noti), ↓PR(50↓ noti)

- HA, Dz, confusion, drowsiness

 

- with or without food, but! 같은시간에 복용 crush X, grape X

 

interact med)

- CCB가 med효과를 ↑는 약들 : theophyll~, β-blocker, digoxin, lithium, cyclosporin, ~statin, steroid

- CCB의 효과를 올려주는 emd : cimetidine, H2 blocker